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1

Characterization of the Ornithine Hydroxylation Step in Albachelin Biosynthesis

Bufkin, Kendra, Sobrado, Pablo

Journal:

Year:

2017

Language:

english

File:

PDF, 1.70 MB

english, 2017

2

Mechanism of N -Hydroxylation Catalyzed by Flavin-Dependent Monooxygenases

Badieyan, Somayesadat, Bach, Robert D., Sobrado, Pablo

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 4.60 MB

english, 2015

3

Biosynthesis of desferrioxamine siderophores initiated by decarboxylases: A functional investigation of two lysine/ornithine-decarboxylases from Gordonia rubripertincta CWB2 and Pimelobacter simplex 3E

Hofmann, Marika, Martin del Campo, Julia S., Sobrado, Pablo, Tischler, Dirk

Journal:

Archives of Biochemistry and Biophysics

Year:

2020

File:

PDF, 1.78 MB

2020

4

In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction

Mehra-Chaudhary, Ritcha, Dai, Yumin, Sobrado, Pablo, Tanner, John J.

Journal:

Year:

2016

Language:

english

File:

PDF, 867 KB

english, 2016

5

In Planta Variation of Volatile Biosynthesis: An Alternative Biosynthetic Route to the Formation of the Pathogen-Induced Volatile Homoterpene DMNT via Triterpene Degradation in Arabidopsis Roots

Sohrabi, Reza, Huh, Jung-Hyun, Badieyan, Somayesadat, Rakotondraibe, Liva Harinantenaina, Kliebenstein, Daniel J., Sobrado, Pablo, Tholl, Dorothea

Journal:

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

6

Sinorhizobium meliloti Chemotaxis to Multiple Amino Acids Is Mediated by the Chemoreceptor McpU

Webb, Benjamin A., Compton, K. Karl, del Campo, Julia S. Martin, Taylor, Doris, Sobrado, Pablo, Scharf, Birgit E.

Journal:

Molecular Plant-Microbe Interactions

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

7

Mechanistic and Structural Studies of H373Q Flavocytochrome b 2 : Effects of Mutating the Active Site Base †,‡

Tsai, Chi-Lin, Gokulan, Kuppan, Sobrado, Pablo, Sacchettini, James C., Fitzpatrick, Paul F.

Journal:

Year:

2007

Language:

english

File:

PDF, 266 KB

english, 2007

8

Structural evidence for rifampicin monooxygenase inactivating rifampicin by cleaving its ansa-bridge

Liu, Li-Kai, Dai, Yumin, Abdelwahab, Heba, Sobrado, Pablo, Tanner, John J

Journal:

Year:

2018

Language:

english

File:

PDF, 625 KB

english, 2018

9

Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics

Campbell, Ashley C., Stiers, Kyle M, Martin Del Campo, Julia S., Mehra-Chaudhary, Ritcha, Sobrado, Pablo, Tanner, John J.

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.08 MB

2020

10

An Unprecedented NADPH Domain Conformation in Lysine Monooxygenase NbtG Provides Insights into Uncoupling of Oxygen Consumption from Substrate Hydroxylation

Binda, Claudia, Robinson, Reeder M., Martin del Campo, Julia S., Keul, Nicholas D., Rodriguez, Pedro J., Robinson, Howard H., Mattevi, Andrea, Sobrado, Pablo

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.50 MB

english, 2015

11

Molecular dynamics simulations of substrate release from Trypanosoma cruzi UDP-galactopyranose mutase

Cossio-P&eacute, rez, Rodrigo, Pierdominici-Sottile, Gustavo, Sobrado, Pablo, Palma, Juliana

Journal:

Journal of Chemical Information and Modeling

Year:

2019

Language:

english

File:

PDF, 7.01 MB

english, 2019

12

Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus

Michelle Oppenheimer, Myles B. Poulin, Todd L. Lowary, Richard F. Helm, Pablo Sobrado

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 1.49 MB

english, 2010

13

Solvent and Primary Deuterium Isotope Effects Show That Lactate CH and OH Bond Cleavages Are Concerted in Y254F Flavocytochrome b 2 , Consistent with a Hydride Transfer Mechanism †

Sobrado, Pablo, Fitzpatrick, Paul F.

Journal:

Year:

2003

Language:

english

File:

PDF, 88 KB

english, 2003

14

Identification of structural determinants of NAD(P)H selectivity and lysine binding in lysine N6-monooxygenase

Abdelwahab, Heba, Robinson, Reeder, Rodriguez, Pedro, Adly, Camelia, El-Sohaimy, Sohby, Sobrado, Pablo

Journal:

Archives of Biochemistry and Biophysics

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

15

Steric Control of the Rate-Limiting Step of UDP-Galactopyranose Mutase

Pierdominici-Sottile, Gustavo, Cossio-Pérez, Rodrigo, Da Fonseca, Isabel, Kizjakina, Karina, Tanner, John J., Sobrado, Pablo

Journal:

Year:

2018

Language:

english

File:

PDF, 1.05 MB

english, 2018

16

Mechanism of Rifampicin Inactivation in Nocardia farcinica

Abdelwahab, Heba, Martin Del Campo, Julia S., Dai, Yumin, Adly, Camelia, El-Sohaimy, Sohby, Sobrado, Pablo, Mariño-Ramírez, Leonardo

Journal:

Year:

2016

Language:

english

File:

PDF, 4.19 MB

english, 2016

17

Recombinant expression, purification, and characterization of ThmD, the oxidoreductase component of tetrahydrofuran monooxygenase

Michelle Oppenheimer, Brad S. Pierce, Joshua A. Crawford, Keith Ray, Richard F. Helm, Pablo Sobrado

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 1.53 MB

english, 2010

18

X-ray structure of a mammalian stearoyl-CoA desaturase

Bai, Yonghong, McCoy, Jason G., Levin, Elena J., Sobrado, Pablo, Rajashankar, Kanagalaghatta R., Fox, Brian G., Zhou, Ming

Journal:

Year:

2015

Language:

english

File:

PDF, 5.55 MB

english, 2015

19

Introduction to flavoproteins: Beyond the classical paradigms

Sobrado, Pablo, Gadda, Giovanni

Journal:

Archives of Biochemistry and Biophysics

Year:

2017

Language:

english

File:

PDF, 833 KB

english, 2017

20

Flavin oxidation in flavin-dependent N -monooxygenases

Robinson, Reeder M., Klancher, Catherine A., Rodriguez, Pedro J., Sobrado, Pablo

Journal:

Protein Science

Year:

2018

Language:

english

File:

PDF, 2.08 MB

english, 2018

21

Analysis of the Role of the Active Site Residue Arg98 in the Flavoprotein Tryptophan 2-Monooxygenase, a Member of the l -Amino Oxidase Family †

Sobrado, Pablo, Fitzpatrick, Paul F.

Journal:

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

22

C4a-Hydroperoxyflavin Formation in N -Hydroxylating Flavin Monooxygenases Is Mediated by the 2′-OH of the Nicotinamide Ribose of NADP +

Robinson, Reeder, Badieyan, Somayesadat, Sobrado, Pablo

Journal:

Year:

2013

Language:

english

File:

PDF, 621 KB

english, 2013

23

Structure, mechanism, and dynamics of UDP-galactopyranose mutase

Tanner, John J., Boechi, Leonardo, Andrew McCammon, J., Sobrado, Pablo

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 5.09 MB

english, 2014

24

Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens

Kizjakina, Karina, J. Tanner, John, Sobrado, Pablo

Journal:

Current Pharmaceutical Design

Year:

2013

Language:

english

File:

PDF, 660 KB

english, 2013

25

Identification of the Binding Region of the [2Fe-2S] Ferredoxin in Stearoyl-Acyl Carrier Protein Desaturase: Insight into the Catalytic Complex and Mechanism of Action †

Sobrado, Pablo, Lyle, Karen S., Kaul, Steven P., Turco, Michelle M., Arabshahi, Ida, Marwah, Ashok, Fox, Brian G.

Journal:

Year:

2006

Language:

english

File:

PDF, 552 KB

english, 2006

26

Author Correction: Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors

Martin del Campo, Julia S., Eckshtain-Levi, Meital, Vogelaar, Nancy J., Sobrado, Pablo

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 664 KB

english, 2018

27

The Chemistry of Cosmic Dust Analogs from C, C 2 , and C 2 H 2 in C-rich Circumstellar Envelopes

Santoro, Gonzalo, MartÃnez, Lidia, Lauwaet, Koen, Accolla, Mario, Tajuelo-Castilla, Guillermo, Merino, Pablo, Sobrado, JesÃºs M., PelÃ¡ez, RamÃ³n J., Herrero, VÃctor J., Tanarro, Isabel, Mayoral, Ã

Journal:

The Astrophysical Journal

Year:

2020

File:

PDF, 1.67 MB

2020

28

Biochemical Characterization of the Two-Component Flavin-Dependent Monooxygenase Involved in Valanimycin Biosynthesis

Li, Hao, Forson, Benedicta, Eckshtain-Levi, Meital, Valentino, Hannah, MartÃn del Campo, Julia S., Tanner, John J., Sobrado, Pablo

Journal:

Year:

2020

File:

PDF, 2.75 MB

2020

29

UDP-galactopyranose mutases from Leishmania species that cause visceral and cutaneous leishmaniasis

Fonseca, Isabel O., Kizjakina, Karina, Sobrado, Pablo

Journal:

Archives of Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 2.75 MB

english, 2013

30

gfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O -glycan in Aspergillus nidulans and Aspergillus fumigatus

Komachi, Yuji, Hatakeyama, Shintaro, Motomatsu, Haruka, Futagami, Taiki, Kizjakina, Karina, Sobrado, Pablo, Ekino, Keisuke, Takegawa, Kaoru, Goto, Masatoshi, Nomura, Yoshiyuki, Oka, Takuji

Journal:

Molecular Microbiology

Year:

2013

Language:

english

File:

PDF, 4.58 MB

english, 2013

31

Flavin-N5 Covalent Intermediate in the Non-redox Dehalogenation Reaction Catalyzed by an Atypical Flavoenzyme

Dai, Yumin, Kizjakina, Karina, Campbell, Ashley C, Korasick, David A, Tanner, John J, Sobrado, Pablo

Journal:

Year:

2017

Language:

english

File:

PDF, 3.76 MB

english, 2017

32

Kinetic Solvent Viscosity Effects as Probes to Study the Mechanisms of Enzyme Action

Gadda, Giovanni, Sobrado, Pablo

Journal:

Year:

2018

Language:

english

File:

PDF, 982 KB

english, 2018

33

Structure and function of a flavin-dependent S-monooxygenase from garlic (Allium sativum)

Valentino, Hannah, Campbell, Ashley C., Schuermann, Jonathan P., Sultana, Nazneen, Nam, Han G, LeBlanc, Sophie, Tanner, John J., Sobrado, Pablo

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 2.15 MB

2020

34

Dual role of NADP(H) in the reaction of a flavin dependent N-hydroxylating monooxygenase

Elvira Romero, Michael Fedkenheuer, Samuel W. Chocklett, Jun Qi, Michelle Oppenheimer, Pablo Sobrado

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2012

Language:

english

File:

PDF, 890 KB

english, 2012

35

Aspergillus fumigatus SidA Is a Highly Specific Ornithine Hydroxylase with Bound Flavin Cofactor

Chocklett, Samuel W., Sobrado, Pablo

Journal:

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

36

Structural Insight into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases

Franceschini, Stefano, Fedkenheuer, Michael, Vogelaar, Nancy J., Robinson, Howard H., Sobrado, Pablo, Mattevi, Andrea

Journal:

Year:

2012

Language:

english

File:

PDF, 848 KB

english, 2012

37

A Protein Structure Initiative approach to expression, purification, and in situ delivery of human cytochrome b5 to membrane vesicles

Pablo Sobrado, Michael A. Goren, Declan James, Carissa K. Amundson, Brian G. Fox

Journal:

Protein Expression and Purification

Year:

2008

Language:

english

File:

PDF, 1.23 MB

english, 2008

38

Inhibition of the flavin-dependent monooxygenase Siderophore A (SidA) blocks siderophore biosynthesis and Aspergillus fumigatus growth

Martin Del Campo, Julia S, Vogelaar, Nancy, Tolani, Karishma, Kizjakina, Karina, Harich, Kim C., Sobrado, Pablo

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

39

Evidence for Formation of a Radical-Mediated Flavin-N5 Covalent Intermediate

Dai, Yumin, Valentino, Hannah R, Sobrado, Pablo

Journal:

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

40

Mechanistic studies on the flavin-dependent N6-lysine monooxygenase MbsG reveal an unusual control for catalysis

Robinson, Reeder M., Rodriguez, Pedro J., Sobrado, Pablo

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 1.25 MB

english, 2014

41

Multimorbidity Patterns in Hospitalized Older Patients: Associations among Chronic Diseases and Geriatric Syndromes

Clerencia-Sierra, Mercedes, Calderón-Larrañaga, Amaia, Martínez-Velilla, Nicolás, Vergara-Mitxeltorena, Itziar, Aldaz-Herce, Pablo, Poblador-Plou, Beatriz, Machón-Sobrado, Mónica, Egüés-Olazabal, Nere

Journal:

Year:

2015

Language:

english

File:

PDF, 384 KB

english, 2015

42

Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase

Qi, Jun, Oppenheimer, Michelle, Sobrado, Pablo

Journal:

Enzyme Research

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

43

Flavin-N5 Covalent Intermediate in a Nonredox Dehalogenation Reaction Catalyzed by an Atypical Flavoenzyme

Dai, Yumin, Kizjakina, Karina, Campbell, Ashley C., Korasick, David A., Tanner, John J., Sobrado, Pablo

Journal:

Year:

2017

File:

PDF, 670 KB

2017

44

Isolation and characterization of functional Leishmania major virulence factor UDP-galactopyranose mutase

Michelle Oppenheimer, Ana L. Valenciano, Pablo Sobrado

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

45

Tryptophan-47 in the active site of Methylophaga sp. strain SK1 flavin-monooxygenase is important for hydride transfer

Han, Andre, Robinson, Reeder M., Badieyan, Somayesadat, Ellerbrock, Jacob, Sobrado, Pablo

Journal:

Archives of Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

46

Probing the Relative Timing of Hydrogen Abstraction Steps in the Flavocytochrome b 2 Reaction with Primary and Solvent Deuterium Isotope Effects and Mutant Enzymes †

Sobrado, Pablo, Daubner, S. Colette, Fitzpatrick, Paul F.

Journal:

Year:

2001

Language:

english

File:

PDF, 87 KB

english, 2001

47

Noncanonical Reactions of Flavoenzymes

Journal:

International Journal of Molecular Sciences

Year:

2012

Language:

english

File:

PDF, 6.67 MB

english, 2012

48

Prevalence of non-aromatic carbonaceous molecules in the inner regions of circumstellar envelopes

Martínez, Lidia, Santoro, Gonzalo, Merino, Pablo, Accolla, Mario, Lauwaet, Koen, Sobrado, Jesús, Sabbah, Hassan, Pelaez, Ramón J., Herrero, Victor J., Tanarro, Isabel, Agúndez, Marcelino, Martín-Jimen

Journal:

Nature Astronomy

Year:

2019

File:

PDF, 1.75 MB

2019

49

Analysis of the roles of amino acid residues in the flavoprotein tryptophan 2-monooxygenase modified by 2-oxo-3-pentynoate: characterization of His338, Cys339, and Cys511 mutant enzymes

Pablo Sobrado, Paul F Fitzpatrick

Journal:

Archives of Biochemistry and Biophysics

Year:

2002

Language:

english

File:

PDF, 251 KB

english, 2002

50

Substrate Binding Modulates the Activity of Mycobacterium smegmatis G, a Flavin-Dependent Monooxygenase Involved in the Biosynthesis of Hydroxamate-Containing Siderophores

Robinson, Reeder, Sobrado, Pablo

Journal:

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

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